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After a penetrating lesion in the central nervous system, astrocytes enlarge, divide, and participate in creating an surroundings that adversely impacts neuronal regeneration. We have just lately proven that the neural cell adhesion molecule (N-CAM) partially inhibits the division of early postnatal rat astrocytes in vitro. Animals were lesioned within the cerebral cortex, hippocampus, or striatum with a Hamilton syringe and needle at defined stereotaxic positions. On one aspect, the lesions had been concomitantly infused with N-CAM or with one of the N-CAM-related molecules.

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Immunohistological Localization Of The Adhesion Molecules L1, N-cam, And Mag In The Developing And Adult Optic Nerve Of Mice

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When N-CAM and primary fibroblast growth factor, which is known to stimulate astrocyte division in vitro, had been coinfused into cortical lesion websites, astrocyte proliferation was still inhibited. These outcomes counsel the speculation that, by decreasing glial proliferation, N-CAM or its peptides might assist create an surroundings that is more appropriate for neuronal regeneration. Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin primary protein in creating sciatic nerve. What used to take a Tricaster/Video Toaster setup can now be carried out in software program using a normal PC. I can swap backwards and forwards between instructor view, demonstration camera, audience view, presentation slide deck or video, etc… and it is seamless. In a nutshell, it actually lets me exhibit the content with out requiring costly technology and having the technology management what can occur.

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